Established in 1968 by Dr. Jose de Guzman Tamayo and his wife Dra. Josefina Laperal Tamayo as Perpetual Help Hospital and College of Nursing, this institution has been training nurses, doctors, maritime, accountants, hrm, allied health, lawyers, engineers and many other courses for service in the Philippines and abroad. Now known as UPHS Jonelta (Jose and Nena Laperal Tamayo), the University of Perpetual Help System Jonelta has campuses in Manila, Binan, GMA Cavite, Isabela, and Malasiqui Pangasinan.

The University of Perpetual Help System DALTA (UPHSD) founded in 1975 by DR./Br.Gen. Antonio L. Tamayo, is a highly recognized university in the Philippines. It has Three major campuses in Las Pinas, Molino, and Calamba. Commission on Higher Education (CHED), Philippines granted deregulated status (equivalent to Autonomous Status) to University of Perpetual Help System DALTA, Manila, Philippines.

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It has about 1,500 academic staff and over 20000 students. UPHSD has attracted various students from across the globe with its quality education and state-of-the-art facilities. It is the destination for creativity, education, discovery, hospitality and innovation. It has six departments namely, Faculty of Medicine, Faculty of Arts and Humanities, Faculty of Business and Social Studies, Faculty of Language and Culture, Faculty of Engineering and Faculty of Science and Technology.

There is an over-1200 bedded hospital named University of Perpetual Help Dalta Medical Centre. UPHSD has one of the highest MCI and USMLE exam passing rates. It has affiliations with hospitals in the United States and also has faculty from reputed universities like Harvard, UCLA, UC Davis, University of London, etc.

On May 18, 2017, CHED through the Chairman, Dr. Patricia Licuanan conferred upon the University of Perpetual Help System DALTA Las Pinas Campus the Autonomous Status. This recognition was received by UPHSD President Anthony Moran Tamayo during the awarding ceremony for higher education institutions and quality assurance partners in celebration of the 23rd founding anniversary of CHED.

UPHSD is continuing its efforts to achieve its objective of maintaining and sustaining excellence in education. It has instituted an extensive network of national and international linkages in higher education and business. It has established its indelible Perpetualite identity as it steadfastly enshrines its Perpetualite values and aspirations.

The University of Perpetual Help System DALTA continuously subscribes to the institutional philosophy that national development and transformation is predicated upon the quality of education of its people. It is committed to the ideals of teaching, community service and research, with “Character Building is Nation Building” as its guiding principle.