Decree of the Cabinet of Ministers of the Republic of Uzbekistan No. 125 dated March 11, 1992 and order of the Ministry of Health of the Republic of Uzbekistan No. 171 dated March 20, 1992 established the Urgench branch of the first Tashkent State Medical Institute on the basis of the Khorezm regional center for advanced training of medical workers.

Later, in accordance with the Decree of the President of the Republic of Uzbekistan, approved on May 31, 1995, and Decree of the Cabinet of Ministers of the Republic of Uzbekistan dated June 3, 1995, the branch was transferred as a medical center with two faculties to Urgench State University.

In accordance with the Decree of the Government of the Republic of Uzbekistan, Resolution of the Cabinet of Ministers of the Republic of Uzbekistan No. 239 dated June 3, 1998, the USU Medical Center was transformed into an independent educational institution – Urgench branch of the first Tashkent State Medical Institute.